Spermidine protects against α-synuclein neurotoxicity
Identifieur interne : 000845 ( Main/Exploration ); précédent : 000844; suivant : 000846Spermidine protects against α-synuclein neurotoxicity
Auteurs : Sabrina Büttner [Autriche, Allemagne] ; Filomena Broeskamp [Autriche, Allemagne] ; Cornelia Sommer [Autriche, Allemagne] ; Maria Markaki [Grèce] ; Lukas Habernig [Autriche] ; Ali Alavian-Ghavanini [Autriche, Allemagne] ; Didac Carmona-Gutierrez [Autriche] ; Tobias Eisenberg [Autriche] ; Eva Michael [Allemagne] ; Guido Kroemer [France] ; Nektarios Tavernarakis [Grèce] ; Stephan J. Sigrist [Allemagne] ; Frank Madeo [Autriche]Source :
- Cell Cycle [ 1538-4101 ] ; 2014.
Abstract
As our society ages, neurodegenerative disorders like Parkinson`s disease (PD) are increasing in pandemic proportions. While mechanistic understanding of PD is advancing, a treatment with well tolerable drugs is still elusive. Here, we show that administration of the naturally occurring polyamine spermidine, which declines continuously during aging in various species, alleviates a series of PD-related degenerative processes in the fruit fly
Url:
DOI: 10.4161/15384101.2014.973309
PubMed: 25483063
PubMed Central: 4614020
Affiliations:
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University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>; Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af0011"><institution>These authors contributed equally to this work.</institution></nlm:aff></affiliation></author><author><name sortKey="Broeskamp, Filomena" sort="Broeskamp, Filomena" uniqKey="Broeskamp F" first="Filomena" last="Broeskamp">Filomena Broeskamp</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>; Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation><nlm:aff id="af0011"><institution>These authors contributed equally to this work.</institution></nlm:aff></affiliation></author><author><name sortKey="Sommer, Cornelia" sort="Sommer, Cornelia" uniqKey="Sommer C" first="Cornelia" last="Sommer">Cornelia Sommer</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>; Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Markaki, Maria" sort="Markaki, Maria" uniqKey="Markaki M" first="Maria" last="Markaki">Maria Markaki</name><affiliation wicri:level="1"><nlm:aff id="af0003"><institution>Institute of Molecular Biology and Biotechnology; Foundation for Research and Technology-Hellas</institution>; Heraklion, Crete,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Habernig, Lukas" sort="Habernig, Lukas" uniqKey="Habernig L" first="Lukas" last="Habernig">Lukas Habernig</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Alavian Ghavanini, Ali" sort="Alavian Ghavanini, Ali" uniqKey="Alavian Ghavanini A" first="Ali" last="Alavian-Ghavanini">Ali Alavian-Ghavanini</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>; Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0004"><institution>Institute of Molecular Biology and Biochemistry; Center for Molecular Medicine; Medical University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Carmona Gutierrez, Didac" sort="Carmona Gutierrez, Didac" uniqKey="Carmona Gutierrez D" first="Didac" last="Carmona-Gutierrez">Didac Carmona-Gutierrez</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eisenberg, Tobias" sort="Eisenberg, Tobias" uniqKey="Eisenberg T" first="Tobias" last="Eisenberg">Tobias Eisenberg</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Michael, Eva" sort="Michael, Eva" uniqKey="Michael E" first="Eva" last="Michael">Eva Michael</name><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>; Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><affiliation wicri:level="1"><nlm:aff id="af0005"><institution>INSERM</institution>, U848; Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Metabolomics Platform; Institut Gustave Roussy</institution>; Villejuif,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0007"><institution>Centre de Recherche des Cordeliers</institution>; Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0008"><institution>Pôle de Biologie; Hôpital Européen Georges Pompidou</institution>; AP-HP; Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0009"><institution>Université Paris Descartes; Sorbonne Paris Cité</institution>; Paris,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tavernarakis, Nektarios" sort="Tavernarakis, Nektarios" uniqKey="Tavernarakis N" first="Nektarios" last="Tavernarakis">Nektarios Tavernarakis</name><affiliation wicri:level="1"><nlm:aff id="af0003"><institution>Institute of Molecular Biology and Biotechnology; Foundation for Research and Technology-Hellas</institution>; Heraklion, Crete,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0010"><institution>Department of Basic Sciences, Faculty of Medicine, University of Crete</institution>; Heraklion, Crete,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sigrist, Stephan J" sort="Sigrist, Stephan J" uniqKey="Sigrist S" first="Stephan J" last="Sigrist">Stephan J. Sigrist</name><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Institute for Biology/Genetics; Freie Universität Berlin</institution>; Berlin,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>Institute of Molecular Biosciences; University of Graz</institution>; Graz,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cell Cycle</title><idno type="ISSN">1538-4101</idno><idno type="eISSN">1551-4005</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>As our society ages, neurodegenerative disorders like Parkinson`s disease (PD) are increasing in pandemic proportions. While mechanistic understanding of PD is advancing, a treatment with well tolerable drugs is still elusive. Here, we show that administration of the naturally occurring polyamine spermidine, which declines continuously during aging in various species, alleviates a series of PD-related degenerative processes in the fruit fly <italic>Drosophila melanogaster</italic> and the nematode <italic>Caenorhabditis elegans</italic>, two established model systems for PD pathology. In the fruit fly, simple feeding with spermidine inhibited loss of climbing activity and early organismal death upon heterologous expression of human α-synuclein, which is thought to be the principal toxic trigger of PD. In this line, administration of spermidine rescued α-synuclein-induced loss of dopaminergic neurons, a hallmark of PD, in nematodes. Alleviation of PD-related neurodegeneration by spermidine was accompanied by induction of autophagy, suggesting that this cytoprotective process may be responsible for the beneficial effects of spermidine administration.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bove, J" uniqKey="Bove J">J Bové</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Arencibia, M" uniqKey="Garcia Arencibia M">M García-Arencibia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, Mt" uniqKey="Lin M">MT Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, E" uniqKey="Wong E">E Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jansen, Ahp" uniqKey="Jansen A">AHP Jansen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dantuma, Np" uniqKey="Dantuma N">NP 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Feany</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooper, Aa" uniqKey="Cooper A">AA Cooper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buttner, S" uniqKey="Buttner S">S Büttner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buttner, S" uniqKey="Buttner S">S Büttner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nuytemans, K" uniqKey="Nuytemans K">K Nuytemans</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brand, Ah" uniqKey="Brand A">AH Brand</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Powers, Km" uniqKey="Powers K">KM Powers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cao, S" uniqKey="Cao S">S Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qiao, L" uniqKey="Qiao L">L Qiao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Samara, C" uniqKey="Samara C">C Samara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jaeger, Pa" uniqKey="Jaeger P">PA Jaeger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, P Y" uniqKey="Pan P">P-Y Pan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pickford, F" uniqKey="Pickford F">F Pickford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spencer, B" uniqKey="Spencer B">B Spencer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hara, T" uniqKey="Hara T">T Hara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Komatsu, M" uniqKey="Komatsu M">M Komatsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berger, Z" uniqKey="Berger Z">Z Berger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ravikumar, B" uniqKey="Ravikumar B">B Ravikumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koike, M" uniqKey="Koike M">M Koike</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, Ct" uniqKey="Chu C">CT Chu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Plowey, Ed" uniqKey="Plowey E">ED Plowey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, J X" uniqKey="Song J">J-X Song</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winslow, Ar" uniqKey="Winslow A">AR Winslow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xilouri, M" uniqKey="Xilouri M">M Xilouri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Decressac, M" uniqKey="Decressac M">M Decressac</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez Revuelta, Bi" uniqKey="Perez Revuelta B">BI Pérez-Revuelta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sarkar, S" uniqKey="Sarkar S">S Sarkar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagy, P" uniqKey="Nagy P">P Nagy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brenner, S" uniqKey="Brenner S">S Brenner</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>France</li><li>Grèce</li></country></list><tree><country name="Autriche"><noRegion><name sortKey="Buttner, Sabrina" sort="Buttner, Sabrina" uniqKey="Buttner S" first="Sabrina" last="Büttner">Sabrina Büttner</name></noRegion><name sortKey="Alavian Ghavanini, Ali" sort="Alavian Ghavanini, Ali" uniqKey="Alavian Ghavanini A" first="Ali" last="Alavian-Ghavanini">Ali Alavian-Ghavanini</name><name sortKey="Alavian Ghavanini, Ali" sort="Alavian Ghavanini, Ali" uniqKey="Alavian Ghavanini A" first="Ali" last="Alavian-Ghavanini">Ali Alavian-Ghavanini</name><name sortKey="Broeskamp, Filomena" sort="Broeskamp, Filomena" uniqKey="Broeskamp F" first="Filomena" last="Broeskamp">Filomena Broeskamp</name><name sortKey="Carmona Gutierrez, Didac" sort="Carmona Gutierrez, Didac" uniqKey="Carmona Gutierrez D" first="Didac" last="Carmona-Gutierrez">Didac Carmona-Gutierrez</name><name sortKey="Eisenberg, Tobias" sort="Eisenberg, Tobias" uniqKey="Eisenberg T" first="Tobias" last="Eisenberg">Tobias Eisenberg</name><name sortKey="Habernig, Lukas" sort="Habernig, Lukas" uniqKey="Habernig L" first="Lukas" last="Habernig">Lukas Habernig</name><name sortKey="Madeo, Frank" sort="Madeo, Frank" uniqKey="Madeo F" first="Frank" last="Madeo">Frank Madeo</name><name sortKey="Sommer, Cornelia" sort="Sommer, Cornelia" uniqKey="Sommer C" first="Cornelia" last="Sommer">Cornelia Sommer</name></country><country name="Allemagne"><noRegion><name sortKey="Buttner, Sabrina" sort="Buttner, Sabrina" uniqKey="Buttner S" first="Sabrina" last="Büttner">Sabrina Büttner</name></noRegion><name sortKey="Alavian Ghavanini, Ali" sort="Alavian Ghavanini, Ali" uniqKey="Alavian Ghavanini A" first="Ali" last="Alavian-Ghavanini">Ali Alavian-Ghavanini</name><name sortKey="Broeskamp, Filomena" sort="Broeskamp, Filomena" uniqKey="Broeskamp F" first="Filomena" last="Broeskamp">Filomena Broeskamp</name><name sortKey="Michael, Eva" sort="Michael, Eva" uniqKey="Michael E" first="Eva" last="Michael">Eva Michael</name><name sortKey="Sigrist, Stephan J" sort="Sigrist, Stephan J" uniqKey="Sigrist S" first="Stephan J" last="Sigrist">Stephan J. Sigrist</name><name sortKey="Sommer, Cornelia" sort="Sommer, Cornelia" uniqKey="Sommer C" first="Cornelia" last="Sommer">Cornelia Sommer</name></country><country name="Grèce"><noRegion><name sortKey="Markaki, Maria" sort="Markaki, Maria" uniqKey="Markaki M" first="Maria" last="Markaki">Maria Markaki</name></noRegion><name sortKey="Tavernarakis, Nektarios" sort="Tavernarakis, Nektarios" uniqKey="Tavernarakis N" first="Nektarios" last="Tavernarakis">Nektarios Tavernarakis</name><name sortKey="Tavernarakis, Nektarios" sort="Tavernarakis, Nektarios" uniqKey="Tavernarakis N" first="Nektarios" last="Tavernarakis">Nektarios Tavernarakis</name></country><country name="France"><noRegion><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name></noRegion><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name><name sortKey="Kroemer, Guido" sort="Kroemer, Guido" uniqKey="Kroemer G" first="Guido" last="Kroemer">Guido Kroemer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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